Charcot, Janet, and Freud all noted that fragmented memories of traumatic events dominated the mental life of many of their patient and built their theories about the nature and treatment of psychopathology on this recognition. Janet 75 thought that traumatic memories of traumatic events persist as unassimilated fixed ideas that act as foci for the development of alternate states of consciousness, including dissociative phenomena, such as fugue states, amnesias, and chronic states of helplessness and depression. Unbidden memories of the trauma may return as physical sensations, horrific images or nightmares, behavioral reenactments, or a combination of these.
Lead researcher Stephen Ferguson believes that the connecting mechanism in the brain explains how stress and anxiety could lead to depression. The study also reveals a small molecule inhibitor, developed by Ferguson, which may provide a new and better way to treat anxiety, depression and other related disorders.
The findings are published online in the journal Nature Neuroscience. Ferguson, Ana Magalhaes and their colleagues used a behavioral mouse model and a series of molecular experiments to reveal the connection pathway and to test the new inhibitor.
While no one has been able to connect these two receptors on a molecular level, the study reveals that CRFR1 works to increase the number of 5-HTRs on cell surfaces in the brain, which can cause abnormal brain signaling. Since CRFR1 activation leads to anxiety in response to stress, and 5-HTRs lead to depression, the research shows how stress, anxiety and depression pathways connect through distinct processes in the brain.
Most importantly, the inhibitor developed by the Ferguson lab blocks 5-HTRs in the pathway to combat anxious behavior, and potentially depression, in mice. While major depressive disorder often occurs together with anxiety disorder in patients, the causes for both are strongly linked to stressful experiences.
Stressful experiences can also make the symptoms of anxiety and depression more severe. By discovering and then blocking a pathway responsible for the link between stress, anxiety and depression, Ferguson not only provides the first biological evidence for a connection, but he also pioneers the development of a potential drug for more effective treatment.
Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness.
Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years.
He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy.
His research efforts included the area of telehealth with a specialty in disease management. Link between Stress, Anxiety, Depression. Retrieved on November 26,from https:Depression has many possible causes, such as genetics, brain chemicals and your life situation.
Chronic stressful life situations can increase the risk of developing depression if you aren't coping with the stress well.
There's also increasing evidence of links among poor coping, stress and physical.
Postpartum Depression; Stress Management Childhood depression is different from the everyday "blues" that most kids get as they develop. "The Use of Medication in Treating Childhood and. Unmasking Depression. An arthritis flare, unexpected changes at home or work, even the start of a new year can create stress and anxiety.
Thes read more >>. Depression is a common yet complex mental health condition affecting more than 16 million adults and 3 million adolescents in the US each year.
People with depression feel sad, empty, or hopeless. Traumatic experiences and stressors in childhood have historically been overlooked as predisposing factors in the development of various chronic pain disorders and psychiatric conditions, including fibromyalgia, irritable bowel syndrome, insomnia, depression, anxiety, post-traumatic stress disorder, and chronic fatigue syndrome.
Table 1. Definitions of Key Terms Gender Typing--The process of developing the behaviors, thoughts, and emotions associated with a particular gender..
Depression--A psychiatric disorder characterized by an inability to concentrate, insomnia, loss of appetite, anhedonia, feelings of extreme sadness, guilt, helplessness and hopelessness, and thoughts of death.